Detailed Notes on Endocannabinoid System
This refers to how an allosteric modulator impacts signaling for a specific orthosteric agonist. By way of example, an allosteric modulator could alter THC signaling, although not endogenous cannabinoid signaling. An important probable endogenous damaging allosteric modulator for CB1 is definitely the steroid hormone, pregnenolone [40–forty two].